Cbl CLIA Kit for Mouse(Mus musculus) | EIAab.comCbl CLIA Kit for Mouse(Mus musculus)

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Cbl (Gene name),

E3 ubiquitin-protein ligase CBL (Protein name ), CBL_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cbl;

Protein name:

E3 ubiquitin-protein ligase CBL;

Alternative:

Proto-oncogene c-Cbl;Casitas B-lineage lymphoma proto-oncogene;Signal transduction protein CBL;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts (phosphorylated) with PIK3R1. Interacts with phosphorylated LAT2 (By similarity). Associates with NCK via its SH3 domain. The phosphorylated C-terminus interacts with CD2AP via its second SH3 domain. Binds to UBE2L3. Interacts with adapters SLA, SLA2 and with the phosphorylated C-terminus of SH2B2. Interacts with EGFR, SYK and ZAP70 via the highly conserved Cbl-N region. Interacts with FGR. Also interacts with BLK, SORBS1 and INPPL1/SHIP2. May interact with CBLB (By similarity). Interacts with ALK, AXL and FGFR2. Interacts with EPHB1; regulates receptor degradation through ubiquitination.

Function:

Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FGFR1, FGFR2, PDGFA, EGF, CSF1, and EPHA8 and terminates signaling. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The Tyr-737 phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function.

Subcellular Location:

Cytoplasm Cell membrane Colocalizes with FGFR2 in lipid rafts at the cell membrane.

Protein Attributes:

Sequence length:

913

Sequence:

50:

100:

150:

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250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

913:

EFVSISSPAH | VAT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P22682

KEGG:

mmu:12402

UniGene:

Mm.266871

SMR:

P22682

Pfam:

PF02262

Uniprot:

P22682

FOR

ELISA Kit for Mouse E3 ubiquitin-protein ligase CBL

Cat.:

E15462h

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Manual:

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Packing:

96T

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ELISA Kit for Mouse E3 ubiquitin-protein ligase CBL

Cat.:

E15462m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase CBL

Cat.:

U15462m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase CBL

Cat.:

U15462h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase CBL

Cat.:

P15462Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase CBL

Cat.:

P15462Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase CBL

Protein for Mouse E3 ubiquitin-protein ligase CBL

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif."
Blake T.J. , Shapiro M. , Morse H.C. III , Langdon W.Y.
Oncogene6:653-657(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];MUTANT 70Z/3
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
strain: NOD.
tissue: Skin.
tissue: Thymus.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
4.

"Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways."
Tanaka S. , Neff L. , Baron R. , Levy J.B.
J. Biol. Chem.270:14347-14351(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LYN;PHOSPHORYLATION
5.

"Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases."
Latour S. , Chow L.M. , Veillette A.
J. Biol. Chem.271:22782-22790(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY SYK
6.

"Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes."
Fournel M. , Davidson D. , Weil R. , Veillette A.
J. Exp. Med.183:301-306(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY ZAP70
7.

"Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules."
Ito N. , Wernstedt C. , Engstrom U. , Claesson-Welsh L.
J. Biol. Chem.273:23410-23418(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FLT1
8.

"A novel, multifunctional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes."
Ribon V. , Printen J.A. , Hoffman N.G. , Kay B.K. , Saltiel A.R.
Mol. Cell. Biol.18:872-879(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SORBS1
9.

"The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha."
Miyake S. , Lupher M.L. Jr. , Druker B. , Band H.
Proc. Natl. Acad. Sci. U.S.A.95:7927-7932(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase."
Howlett C.J. , Bisson S.A. , Resek M.E. , Tigley A.W. , Robbins S.M.
Biochem. Biophys. Res. Commun.257:129-138(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY HCK;INTERACTION WITH HCK
11.

"The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation."
Lee P.S. , Wang Y. , Dominguez M.G. , Yeung Y.G. , Murphy M.A. , Bowtell D.D. , Stanley E.R.
EMBO J.18:3616-3628(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling."
Loreto M.P. , Berry D.M. , McGlade C.J.
Mol. Cell. Biol.22:4241-4255(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLA2 AND ZAP70;MUTAGENESIS OF GLY-304
13.

"Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells."
Duval M. , Bedard-Goulet S. , Delisle C. , Gratton J.P.
J. Biol. Chem.278:20091-20097(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KDR;FUNCTION
14.

"The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport."
Liu J. , DeYoung S.M. , Hwang J.B. , O'Leary E.E. , Saltiel A.R.
J. Biol. Chem.278:36754-36762(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBLB
15.

"The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1)."
Kobayashi S. , Sawano A. , Nojima Y. , Shibuya M. , Maru Y.
FASEB J.18:929-931(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FLT1 AND CD2AP;PHOSPHORYLATION IN RESPONSE TO VEGFA
16.

"The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation."
Pakuts B. , Debonneville C. , Liontos L.M. , Loreto M.P. , McGlade C.J.
J. Biol. Chem.282:17953-17963(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;INTERACTION WITH SLA2 AND CSF1R
17.

"Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation."
Reddi A.L. , Ying G. , Duan L. , Chen G. , Dimri M. , Douillard P. , Druker B.J. , Naramura M. , Band V. , Band H.
J. Biol. Chem.282:29336-29347(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDGFRB
18.

"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-666; SER-667 AND TYR-672;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Mast cell.
19.

"Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking."
Nonis D. , Schmidt M.H. , van de Loo S. , Eich F. , Dikic I. , Nowock J. , Auburger G.
Cell. Signal.20:1725-1739(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATX2
20.

"Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway."
Fasen K. , Cerretti D.P. , Huynh-Do U.
Traffic9:251-266(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPHB1;PHOSPHORYLATION
21.

"The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction."
Sun J. , Pedersen M. , Ronnstrand L.
J. Biol. Chem.284:11039-11047(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF KIT;PHOSPHORYLATION
22.

"The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors."
Kim J. , Lee H. , Kim Y. , Yoo S. , Park E. , Park S.
Mol. Cell. Biol.30:1582-1592(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF EPHA8

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